Can Vitamin C be used as an anticancer agent? Researchers reviewed “to survey the literature to analyze the antitumor effects of vitamin C in both human and animal studies”. This study attempts to address antitumor activities of vitamin C in roden models and safety of the use of vitamin C alone and in conjunction with chemotherapy.
In the 1970s, it was suggested that vitamin C has chemotherapeutic effect. Since then, utilization of vitamin C therapy has increased although its rates remain uncertain.
In Conclusion of this research, the researches say “Vitamin C is well known for its antioxidant activity, but it is the proposed pro-oxidant activity at high concentrations that remains controversial. This situation is perpetuated by the lack of a defined mechanism of action. While intracellular and extracellular generation of H2O2 is the most common theory, clarification of this and determination whether this will translate to a clinical benefit is critical in future research.”
“There are highly polarized views on the use of high-dose vitamin C for cancer treatment, with passionate advocates balanced by passionate critics. This is a key reason for why carefully controlled clinical trials, rather than a review of the literature, are needed to obtain a clear view of this field.”, conclude the reviewers.
Read more about the review of high-dose intravenous vitamin C as an anticancer agent from Asia-Pacific Journal of Clinical Oncology on Wiley Online Library. This article is from ASCO 2014: Clinical Oncology Virtual Issue. Read all other interesting articles free until July 31, 2014!