|Neuroinflammation, defined as the activation of endogenous glial cells and their complex interplay with other cell types via cytokines, chemokines and other factors, is a component of all central nervous system (CNS) injuries, infections, and neurodegenerative diseases. Although neuroinflammation is a normal response to CNS injury, a great deal of emphasis has been placed on its potential negative effects and how these might be modified to effect better outcome in CNS disorders. To this end, multiple models of neuroinflammation have been developed for use in preclinical animal studies.|
In this webinar, Dr. Kerry O’Banion (University of Rochester) will discuss several different models of neuroinflammation and provide an overview of their use in studies of neurodegenerative disease. Emphasis will be placed on differences between the models, including considerations for their implementation and limitations in interpreting results.
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|Dr. M. Kerry O’Banion is Professor and Interim Chair of the Department of Neurobiology & Anatomy at the University of Rochester School of Medicine & Dentistry, and has been involved in neuroinflammation research for over 20 years. Dr. O’Banion received his MD and PhD in Microbiology from the University of Illinois in Champaign-Urbana in 1987, and from 1987-1991 was postdoctoral fellow and instructor in the laboratory of Dr. Donald Young in the Department of Biochemistry at the University of Rochester. During this time, Dr. O’Banion’s work exploring the role of glucocorticoids in rapid modulation of transformed cell phenotype led to the identification and cloning of cyclooxygenase-2, and recognition of its importance in inflammation. In 1991, Dr. O’Banion was appointed Assistant Professor in Neurology at the University of Rochester, and initiated a series of studies examining the role of cyclooxygenase and neuroinflammation in Alzheimer’s pathogenesis using cell culture models and human tissue. These studies were extended to animal models with long-time collaborators Drs. John Olschowka and Stephanos Kyrkanides. In addition to work in Alzheimer’s disease, Dr. O’Banion’s laboratory pursues work in other neurodegenerative diseases and is investigating the role of neuroinflammation in hippocampal neurogenesis and injury following CNS radiation exposure. His laboratory currently receives funding from NIA, NIAID, NIEHS and NASA. In addition to research, Dr. O’Banion also oversees training of 60-65 MD-PhD students as Director of the University of Rochester’s Medical Scientist Training Program.|
Moderator: Dr. Gwen Taylor is the Senior Developmental Editor and Webinar Program Manager for Current Protocols, Wiley publishers.
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